|
|
5-diphosphomevalonate + ATP <=> isopentenyl_diphosphate + CO2 + ADP + phosphate
|
4.1.1.33
diphosphomevalonate decarboxylase
|
–
|
| |
BRENDA:
BR292
KEGG:
R01121
MetaCyc:
DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN
SABIO-RK:
1380
|
|
|
|
acetoacetyl-CoA + H2O + acetyl-CoA <=> H+ + CoA + (S)-3-hydroxy-3-methylglutaryl-CoA
|
2.3.3.10
hydroxymethylglutaryl-CoA synthase
|
–
|
| |
BRENDA:
BR44119
KEGG:
R01978
MetaCyc:
HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN
SABIO-RK:
2021
|
|
|
|
(R)-mevalonate + ATP <=> H+ + (R)-5-phosphomevalonate + ADP
|
2.7.1.36
mevalonate kinase
|
–
|
| |
BRENDA:
BR47775
KEGG:
R02245
MetaCyc:
MEVALONATE-KINASE-RXN
SABIO-RK:
2215
|
|
|
|
isopentenyl_diphosphate <=> dimethylallyl_diphosphate
|
5.3.3.2
isopentenyl-diphosphate Delta-isomerase
|
–
|
| |
BRENDA:
BR247
KEGG:
R01123
MetaCyc:
IPPISOM-RXN
SABIO-RK:
1382
|
|
|
|
NADP+ + CoA + (R)-mevalonate <=> H+ + NADPH + (S)-3-hydroxy-3-methylglutaryl-CoA
|
1.1.1.34
hydroxymethylglutaryl-CoA reductase (NADPH)
1.1.1.88
hydroxymethylglutaryl-CoA reductase
1.1.1.B38
|
–
–
–
|
| |
BRENDA:
BR29297;
BR50597;
BS188050;
BS451044
KEGG:
R02082
MetaCyc:
1.1.1.34-RXN
SABIO-RK:
2092
|
|
|
|
(R)-5-phosphomevalonate + ATP <=> 5-diphosphomevalonate + ADP
|
2.7.4.2
phosphomevalonate kinase
|
–
|
| |
BRENDA:
BR48074
KEGG:
R03245
MetaCyc:
PHOSPHOMEVALONATE-KINASE-RXN
SABIO-RK:
3066
|
|
|
|
acetyl-CoA <=> acetoacetyl-CoA + CoA
|
1.1.1.34
hydroxymethylglutaryl-CoA reductase (NADPH)
2.3.1.155
acetyl-CoA C-myristoyltransferase
2.3.1.16
acetyl-CoA C-acyltransferase
2.3.1.38
[acyl-carrier-protein] S-acetyltransferase
2.3.1.9
acetyl-CoA C-acetyltransferase
|
–
–
–
–
–
|
| |
BRENDA:
BR44092
KEGG:
R00238
MetaCyc:
ACETYL-COA-ACETYLTRANSFER-RXN
SABIO-RK:
531
|
|
